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Enterobacterales are intrinsically resistant to-
Following members of Enterobacterales are also resistant to following antibiotics:
R = Resiatant
1. Azithromycin is effective in vivo for the treatment of typhoid fever and erythromycin may be used to treat travellers’ diarrhea.
2. For Salmonella spp and Shigella spp aminoglycoside, 1st and 2nd Generation Cephalosporines and Cephamycines may appear active in vitro but not effective clinically and should not report as susceptible.
Non-fermentative Gram-negative bacteria are generally intrinsically resistant to-
Some members of non-fermentative Gram-negative bacteria are also intrinsically resistant to-
R = resistant
1 Acinetobacter baumannii may appear to be susceptible to ampicillin-sulbactam due to activity of sulbactam with this species.
2,3 Acinetobacter is intrinsically resistant to tetracycline and doxycycline but not to minocycline and tigecycline.
4 Pseudomonas aeruginosa is intrinsically resistant to kanamycin and neomycin due to low level APH(3’)-IIb activity.
Gram-negative bacteria other than Enterobacteriaceae and non-fermentative Gram-negative bacteria listed are intrinsically resistant to -
Some members of this group also resistant to-
R = resistant
Gram-positive bacteria are intrinsically resistant to-
Other members of this group are also resistant to-
R = resistant
1 Low-level resistance (LLR) to aminoglycosides
2 In addition to LLR to aminoglycosides, Enterococcus faecium produces a chromosomal AAC(6’)-I enzyme that is responsible for the loss of synergism between aminoglycosides (except gentamicin, amikacin and streptomycin) and penicillins or glycopeptides.
Rule 5: Intrinsic resistance in anaerobes. Anaerobes are also intrinsically resistant to aztreonam, aminoglycosides, polymyxin B/colistin and nalidixic acid.
