3.2 Oral antidiabetic drugs (OADs)

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Oral drugs are not recommended in type 1 DM, and during pregnancy and lactation.

Table 3.6 Different classes of OADs

Table 3.6 Different classes of OADs

Table 3.7 Selection issues of an oral agent

Table 3.7 Selection issues of an oral agent

NB: NAFLD - Non-alcoholic fatty liver. eGFR ml/min/1.73m2. MTC - medullary thyroid cancer.
MEN-2 - multiple endocrine neoplasia syndrome type 2.

Special note:

  • Two secretagogues cannot be prescribed together.
  • One secretagogue cannot be replaced by other in case of failure of one secretagogue to achieve glycemic target.
  • Secretagogue needs to be discontinued when twice daily insulin is started.

Table 3.8 Initiation and dose titration of OADs2,4,5

Table 3.8 Initiation and dose titration of OADs2,4,5

NB: ac - before meal. pc - after meal.