III. Mixed Infection

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Mixed malaria infections are common in endemic areas. In Bangladesh Plasmodium falciparum and vivax are common mixed malarial infections. Mixed infections are best detected by nucleic acid-based amplification techniques, such as PCR; they may be underestimated with routine microscopy.

Several RDTs can't detect mixed infection or have low sensitivity for detection of vivax malaria. BSE is preferable over RDT in mixed infection.

N.B:

❖ Results of RDT may be false positive in patient who received antimalarial drugs over 4 weeks.

❖ Very low parasite count may be missed by RDT.