12.2 Testing for latent tuberculosis infection

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Either a tuberculin skin test (TST) using standardised PPD of recommended strength or IGRA can be used to test for LTBI. However, IGRA should not replace TST. Neither TST nor IGRA can differentiate between active and latent TB. Individuals should be asked about symptoms of TB before being tested for LTBI. Chest radiography can be done if efforts are intended also for active TB case finding. Individuals with TB symptoms or any radiological abnormality should be investigated further for active TB and other conditions. TPT should never be prescribed without ruling out active TB disease by symptom screening, and if required, by Chest X Rays and sputum examination.