9.3 Targeting Risk Groups for DST for Second-line Drugs

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Drug susceptibility testing for second-line anti TB drugs enables case-finding for XDR TB and guides proper treatment.

  • All the patient diagnosed as RR TB by GeneXpert will be subjected to second line DST on LPA.
  • Those with resistance to Fluoroquinolones would be subjected to phenotypic culture and DST (preferably liquid C-DST).
  • Extended DST for high dose Mfx (1μg/ml), BDQ, Lzd and Cfz will be performed for guiding DST based treatment.

DST for Z, BDQ and DLM (by MGIT) will be started at NTRL and RTRLs in a phased manner.