Sickle Cell Disease - Infection Prophylaxis

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Malaria prophylaxis
Deltaprim to all patients with sickle cell anaemia. A tablet contains pyrimethamine at 12.5 mg and dapsone at 100 mg.

Dosing:

• Infancy up to 3 years of age ¼ tablet once weekly PO,
• 3-10 years old ½ tablet once weekly PO and
• Over 10 years old 1 tablet once weekly PO.

In event of allergy to deltaprim, use dapsone once weekly orally.Penicillin prophylaxis

• Penicillin V 125 mg BD PO daily for 2 months – 3 years
• Penicillin V 250mg BD PO daily for > 3 years.
• Substitute with erythromycin if penicillin hypersensitivity present.

Discontinuing penicillin prophylaxis can be considered for patients aged 5 years and older who meet the
criteria below:

• Patients without prior history of documented pneumococcal infection
• Patients who have received 1 dose of PPV (pneumococcal 23) and appropriate PCV 13 doses).
• Never had a splenectomy.